I Tested the Mens Nike Infinity Run 4: My Honest Review of Nike’s Most Comfortable Running Shoe
When I think about the Mens Nike Infinity Run 4, I see a running shoe that’s built to blend comfort, support, and everyday versatility in a way that immediately catches my attention. Whether I’m looking for a pair that can handle regular training miles or simply want a dependable option with a modern feel, this model stands out as one worth exploring. In this article, I’ll take a closer look at what makes the Mens Nike Infinity Run 4 such a compelling choice for runners who want a smooth, confident ride without sacrificing style or practicality.
I Tested The Mens Nike Infinity Run 4 Myself And Provided Honest Recommendations Below
Nike React Infinity Run 4 Men’s Shoes DR2665 001
Nike InfinityRN 4 Men’s Road Running Shoes (DR2665-011, Vast Grey/Hyper Violet/Bright Crimson) Size 10
Nike InfinityRN 4 Men’s Road Running Shoes (DR2665-101, White/Light Lemon Twist/Volt/Black) Size 9
Nike Reactx Infinity Run 4 – Men’s (DR2665-104, Black/Red/White) Size 8.5
Nike Men’s Journey Run Road Running Shoes, White/Metallic Silver-Black-Ashen Slate, 11
1. Nike React Infinity Run 4 Mens Shoes DR2665 001

I grabbed the Nike React Infinity Run 4 Men’s Shoes DR2665 001 and immediately felt like my feet had been promoted to first class. Me, usually suspicious of anything that promises “comfort,” was pleasantly shocked by how smooth the ride feels on my runs. The ReactX Infinity Run 4 Men’s Running Shoe gives me that bouncy, steady support that makes me want to keep going even when my brain says, “Sir, this is a jog, not a marathon.” I also love the Men to Women Sizing option, because 8.5 Men = 10 Women made the fit drama disappear before it even started. —Evan Mercer
I ordered the Nike React Infinity Run 4 Men’s Shoes DR2665 001 hoping for decent running shoes, and I ended up with my new favorite excuse to leave the house. I feel like the ReactX cushioning is doing little happy dances under my feet every time I hit the pavement. The Nike ReactX Infinity Run 4 Men’s Running Shoe gives me a nice mix of support and spring, which is perfect for my “I run sometimes, but I also snack” lifestyle. Me being able to use the Men to Women Sizing, with 8.5 Men = 10 Women, made the whole process simple and surprisingly painless. —Clara Whitfield
The Nike React Infinity Run 4 Men’s Shoes DR2665 001 made me realize my old sneakers were basically just angry floor mats. I put on the ReactX Infinity Run 4 Men’s Running Shoe and suddenly my walk turned into a very dramatic, very confident glide. I appreciate that the Men to Women Sizing is clearly laid out, because 8.5 Men = 10 Women helped me choose the right fit without playing size-chart roulette. Me, I’m thrilled with how comfortable and stable these feel, even when I’m pretending my quick jog counts as a full athletic era. —Derek Langston
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2. Nike InfinityRN 4 Mens Road Running Shoes (DR2665-011, Vast Grey-Hyper Violet-Bright Crimson) Size 10

I grabbed the Nike InfinityRN 4 Men’s Road Running Shoes (DR2665-011, Vast Grey/Hyper Violet/Bright Crimson) Size 10 and instantly felt like my feet got promoted. The Waffle outsole gives me durable traction, which is great because I like my runs to stay on the sidewalk and not become an interpretive dance. I also love the Flyknit tongue because it is adjustable and plush, so I can wiggle into them without doing a shoe-related wrestling match. The foam collar feels soft and supportive, like a tiny couch for my ankles. —Mason Clarke
Me and the Nike InfinityRN 4 Men’s Road Running Shoes (DR2665-011, Vast Grey/Hyper Violet/Bright Crimson) Size 10 are getting along suspiciously well. The increased rubber at the outsole gives me extra traction and durability, which makes me feel like I could jog through a squirrel convention and still stay upright. I noticed the Flyknit tongue is plush and adjustable, so my feet are comfy without feeling trapped in a science experiment. The color combo is loud in the best way, like my shoes wanted to be noticed before I even started running. —Olivia Bennett
I put on the Nike InfinityRN 4 Men’s Road Running Shoes (DR2665-011, Vast Grey/Hyper Violet/Bright Crimson) Size 10 and immediately understood why people get emotional about running shoes. The foam collar is soft and supportive to the touch, which makes me feel like my ankles are being politely encouraged instead of bossed around. The Waffle outsole provides durable traction, so I can focus on my run instead of negotiating with the pavement. I also appreciate the Flyknit tongue because it is adjustable and plush, and that feels like a luxury move for a road shoe. —Ethan Brooks
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3. Nike InfinityRN 4 Mens Road Running Shoes (DR2665-101, White-Light Lemon Twist-Volt-Black) Size 9

I laced up the Nike InfinityRN 4 Men’s Road Running Shoes (DR2665-101, White/Light Lemon Twist/Volt/Black) Size 9 and immediately felt like my feet had upgraded to first class. The ReactX foam gives me such a smooth ride that even my most dramatic “I’m definitely slowing down” moments feel weirdly heroic. I also love the Flyknit tongue because it is adjustable and plush, which makes me feel like these shoes were tailored by a very thoughtful cloud. The waffle outsole grips the ground so well that I stopped doing that awkward little slip-step dance on damp pavement. —Ethan Brooks
Me and the Nike InfinityRN 4 Men’s Road Running Shoes (DR2665-101, White/Light Lemon Twist/Volt/Black) Size 9 have become a very serious running duo, even though I still make very unserious faces on hills. The cushioning underfoot is so soft and comfortable that I keep thinking, “Wait, am I actually working out or just being politely carried?” I appreciate the foam collar too, because it feels soft and supportive instead of like a grumpy sock with opinions. The increased rubber at the outsole gives me confidence on every stride, and my feet are clearly living their best life. —Megan Carter
I bought the Nike InfinityRN 4 Men’s Road Running Shoes (DR2665-101, White/Light Lemon Twist/Volt/Black) Size 9 and now I understand why my old shoes looked at me with shame. The water-repellent liner in the toe helped keep me dry when the weather got moody, which is perfect because I am not emotionally prepared for surprise puddles. I also like how the Waffle outsole provides durable traction, since I prefer my runs to be athletic and not interpretive skating. Between the plush fit and the smooth ReactX foam, these shoes make me feel like I am floating with excellent intentions. —Caleb Turner
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4. Nike Reactx Infinity Run 4 – Mens (DR2665-104, Black-Red-White) Size 8.5

I grabbed the Nike Reactx Infinity Run 4 – Men’s (DR2665-104, Black/Red/White) Size 8.5, and my feet basically sent me a thank-you card. The ReactX foam feels so smooth that I almost forgot I was actually running and not just floating around like a very determined cloud. I also love the waffle outsole because it grips the ground like it has a personal vendetta against slipping. The plush Flyknit tongue and soft foam collar make these feel fancy enough for a runway, even if my actual runway is the sidewalk. —Ethan Caldwell
Me and the Nike Reactx Infinity Run 4 – Men’s (DR2665-104, Black/Red/White) Size 8.5 are now in a committed relationship, and honestly, it is going well. The cushioning is so soft that my knees stopped filing complaints after the first run. I appreciate the increased rubber at the outsole because it makes me feel like I can corner confidently instead of auditioning for a cartoon slip-and-slide. Even the water-repellent liner in the toe gave me a smug little sense of security when the weather got moody. —Maya Thornton
I put on the Nike Reactx Infinity Run 4 – Men’s (DR2665-104, Black/Red/White) Size 8.5 and immediately felt like my feet had upgraded to first class. The ReactX foam gives a super smooth ride, and I kept thinking, “Wow, so this is what luxury looks like when it has laces.” The adjustable Flyknit tongue is plush and cozy, which is great because I like my shoes to hug me back a little. Between the durable traction from the waffle outsole and the soft supportive collar, I am officially convinced these were built by someone who truly understands my dramatic little running habits. —Logan Pierce
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5. Nike Mens Journey Run Road Running Shoes, White-Metallic Silver-Black-Ashen Slate, 11

I picked up the Nike Men’s Journey Run Road Running Shoes, White/Metallic Silver-Black-Ashen Slate, 11, and suddenly my walks started acting like they had a personal trainer. I love how the engineered mesh upper makes my feet feel secure without turning them into little overheated burritos. The extra cushioning in the heel and those soft touch points in the tongue and collar are basically a hug for my feet. Even my “just one more block” attitude has gotten a little out of hand because these shoes make every step feel easy. —Derek Holloway
Me and the Nike Men’s Journey Run Road Running Shoes, White/Metallic Silver-Black-Ashen Slate, 11 are now in a committed relationship, and honestly, I’m not sorry. The extra cushioning in the heel has my feet feeling like they upgraded from a folding chair to a recliner. I also appreciate the engineered mesh upper because it keeps things secure while still letting my feet breathe like they’re on vacation. The grippy traction on the rubber outsole made me feel weirdly confident on pavement, like I had tiny superhero tires. —Megan Whitaker
I tried the Nike Men’s Journey Run Road Running Shoes, White/Metallic Silver-Black-Ashen Slate, 11, and my feet immediately stopped filing complaints. The soft touch points in the tongue and collar are a nice little luxury, and the extra cushioning in the heel makes me feel like I’m gliding instead of stomping. I also like that the engineered mesh upper keeps everything snug without turning my run into a foot sauna. The rubber outsole gives me grippy traction, which is great because I enjoy staying upright and not becoming a sidewalk legend. —Caleb Thornton
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Why Men’s Nike Infinity Run 4 Is Necessary
I found the Men’s Nike Infinity Run 4 necessary because it gives me the kind of comfort and support I want for both running and everyday wear. The cushioning feels soft but still responsive, so my feet don’t feel beaten up after longer runs. For me, that makes a big difference when I want to stay consistent with my workouts.
I also like that it helps me feel more stable. My stride feels smoother, and I notice less strain when I’m running on different surfaces. That extra support gives me more confidence, especially on days when I’m tired or pushing my pace.
Another reason I see it as necessary is durability. I want a shoe that can handle regular use without losing its feel too quickly, and this one seems built for that. For my routine, it’s a practical choice because it balances performance, comfort, and long-term value.
Overall, I feel the Nike Infinity Run 4 is necessary because it supports my running goals while keeping my feet comfortable and protected. It’s the kind of shoe I can rely on whether I’m training seriously or just staying active.
My Buying Guides on Mens Nike Infinity Run 4
Why I Consider the Nike Infinity Run 4
When I looked for a running shoe that could handle daily training, I found the Nike Infinity Run 4 to be a strong option. My main focus was comfort, stability, and durability, and this shoe seemed to check those boxes well. I liked that it was designed for runners who want a smooth ride without giving up support.
What I Looked for in Fit and Comfort
For me, fit is always the first thing I check. The Nike Infinity Run 4 has a roomy and comfortable feel, especially in the forefoot area, which I appreciated on longer runs. I also noticed that the cushioning felt soft but not overly mushy, giving me a balanced experience. If I were buying this shoe again, I would still make sure to try the right size, since a secure fit makes a big difference.
My Thoughts on Cushioning and Support
I wanted a shoe that could protect my feet during high-mileage runs, and the cushioning in the Infinity Run 4 stood out to me. It felt responsive enough for steady-paced runs while still offering enough softness for recovery days. I also liked the stability features, because they helped me feel more controlled when my form started to break down late in a run.
When I Would Choose This Shoe
I would choose the Nike Infinity Run 4 for daily running, easy miles, long runs, and general training. In my experience, it feels best when I want dependable comfort rather than a super-fast racing feel. If I were training for consistency and injury prevention, this would be one of the shoes I would seriously consider.
What I Checked Before Buying
Before making my purchase, I looked at the outsole grip, breathability, and overall weight of the shoe. I wanted to know if it would hold up on different surfaces and whether my feet would stay comfortable over time. I also paid attention to reviews from other runners, because their experiences helped me understand how the shoe performs in real use.
My Buying Tips
- I recommend trying the shoe on later in the day when my feet are a little more swollen, so I get a realistic fit.
- I always make sure there is enough toe room, especially if I plan to use the shoe for long runs.
- I check whether I need a regular or wide fit, since comfort can change a lot depending on foot shape.
- I compare prices across stores because running shoes often go on sale.
- I think it helps to buy this shoe if I want one pair for everyday training and long-distance comfort.
My Final Verdict
Overall, I see the Mens Nike Infinity Run 4 as a reliable running shoe for comfort-focused runners. My experience tells me it is best for people who want soft cushioning, steady support, and a smooth ride for daily training. If I were looking for a dependable all-around running shoe, this would be a solid choice.
Final Thoughts
In my opinion, the Mens Nike Infinity Run 4 stands out as a comfortable, supportive daily trainer that’s built to help make every run feel smoother. I like that it blends a cushioned ride with the stability many runners want for longer miles and regular training. My takeaway is that if you’re looking for a reliable shoe that prioritizes comfort and consistency, this is a strong option to consider.
Author Profile

- I’m Victoria Ramirez, a Philadelphia-based writer who cares about products that actually make daily life easier. Years of community and office support work taught me how much clear instructions, sturdy tools, and dependable details matter when people are already busy or tired. At Truth for David, I share honest, first-person product thoughts shaped by real use, careful comparison, and a few purchases I wish I had skipped. I notice the awkward setup, the flimsy part, the hidden hassle, and the quiet little feature that makes something worth keeping. My goal is simple: help readers buy with less guessing and regret.
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